Calorie restriction and improved cognitive functioning

One of the first questions many people ask after going a few rounds with their senior moment brains is: can the decline be reversed? These are often the questions asked by people who want to increase their life span. The surprising answer to both questions, in a few cases described below, is yes.

Executive summary: The decreased cognitive functioning in aging brains appears to be related to changes in gene expression patterns which in turn affects functonal connectivity of neurons. These global gene expression patterns of aging cells can be slowed or reversed by elevated levels of the SIR2 protein. Calorie restriction leads to elevated levels of SIR2. It may also be possible to produce the same effect without the calorie restriction part, living better through chemistry. To which I can only say, faster, please.

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